Very loosely speaking, the more you care about control of your data and the underlying formats, the more additional work you'll have to do yourself (figuring out how to handle filesync, migrations, etc.). Beyond that, there are a variety of other considerations: privacy, built-in linking, WYSIWYG editing, render modes, web clipping, and so on. The best way for you to get a feel for what matters to you is to just try out a few different tools and see what you like.